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The movie “Sun ladki sasarchi” is a Marathi movie by Prashant Patil in which Sunidhi Chauhan, Mukesh Rishi, Ashish Vidyarthi, Harshaali Malaviya, and Bhalchandra Kadam star.
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Check out the recommendations and download your favorite music and videos without having to leave a site.Post-transplant antibodies directed against antigens encoded by the major histocompatibility complex class I, II and class III in patients with multiple myeloma.
Multiple myeloma (MM) is a neoplasm of bone marrow plasma cells and is a disease that is cured by allogeneic stem cell transplantation in approximately 30% of the patients. Anti-HLA antibodies (AHAs) are implicated in graft-vs.-host disease and may also contribute to immune evasion of myeloma cells. This study was performed to determine the frequency of anti-HLA antibodies, both pre- and post-transplant, in MM patients who underwent allogeneic transplantation (n = 26). To this end, we assessed the presence of pre- and post-transplant AHAs directed against HLA class I (A, B, C), class II (DR, DQ), and class III (Ig) molecules. Pre-transplant AHAs were detected in 11 (42%) patients and post-transplant in 15 (58%) patients; eight (31%) patients had more than one antibody. Seven (27%) patients had serum AHAs after the transplant, which were mainly directed against HLA class I and II molecules. No significant differences were found in the occurrence of post-transplant AHAs in relation to donor type (HLA-identical sibling vs matched unrelated donor) or conditioning regimen (MAC vs RIC). No association was found between the presence of post-transplant AHAs and survival time. These results are in accordance with those previously reported. Thus, the detection of pre- and post-transplant AHAs could help to identify patients at risk of acute GVHD and, consequently, to develop strategies to avoid this complication after transplant.DESCRIPTION: (Applicant’s Abstract) The processes by which animals from a variety of phyla form attachments to each other’s body surface have been at the focus of much attention in recent years. Despite a rich literature on this topic in several phyla, there is surprisingly little information about attachment in mammals. The aim of this proposal is to begin the process of