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Tags: Homebrew, Gameboy Advance, GBA Emulator, GBA Emulators, Gba, Gba Dongle, Gba Dongles, Gba Guide, Gba Guides, Gba Downloads, Gba Downloads, Gba Emulator.Loss of lipid droplet-like structures in human breast cancer cell lines MCF-7 and MDA-MB231 is mediated by lipid droplet-associated protein 3 and the tumor suppressor protein menin.
Lipid droplets are ubiquitous membrane-less cytoplasmic organelles that comprise neutral lipids and proteins and store energy reserves. We identified the human homologue of mouse lipid droplet-associated protein (LAP)3 as a candidate biomarker for breast cancer. LAP3 is a protein that promotes clustering of lipid droplets. Loss of LAP3 was associated with the loss of lipid droplets and overexpression of LAP3 enhanced intracellular lipid droplet formation and cluster formation. The subcellular localization and the interaction of LAP3 with lipid droplets were examined. Immunocytochemistry showed that LAP3 localized on lipid droplets, and co-localization of LAP3 with fatty acid-binding protein 4 and 3-hydroxy-3-methylglutaryl coenzyme A reductase suggested that LAP3 localizes to lipid droplets in human breast cancer cell lines MCF-7 and MDA-MB231. Immunoprecipitation of LAP3 from MCF-7 and MDA-MB231 cells showed specific interaction with the tumor suppressor protein menin. Loss of LAP3 was associated with reduction of the levels of menin as well as the interaction between menin and LAP3. These observations provide new insights into the functional role of the tumor suppressor protein menin in regulating a novel component of the subcellular machinery for lipid droplets and raise the possibility of LAP3 as a novel biomarker for breast cancer.Questionable Life Implantable Defibrillator After Cloth-Covered Riata Stent
When a patient has an implantable cardioverter-defibrillator (ICD), this device can recognize a “shockable” arrhythmia, such as ventricular
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PS: You might also want to check out my projects on GitHub. They are probably outdated but it’s an interesting place to get insights into what’s going on in the open source world of spring-data.
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